Johnson & Johnson, founded in 1886 in New Brunswick, New Jersey, is one of the world's major pharmaceutical, medical device, and consumer packaged products manufacturers. In 2022, the company's total sales was 94.9 billion US dollars. As previously stated, the corporation is divided into three main business segments: medical devices and diagnostics, pharmaceuticals, and consumer packaged goods, with the latter accounting for 15 billion US dollars of the company's global revenue in 2022.

Since 2014, the company's pharmaceutical business has grown in importance. Pharmaceuticals currently account for around 55 percent of the company's total sales. Immunology and oncology are the most important therapeutic areas within Johnson & Johnson's pharmaceutical sector. Johnson & Johnson is also involved in infectious diseases and vaccinations. The business applied to the FDA (U.S. Food and Drug Administration) for emergency use permission for its COVID-19 vaccine in February 2021. There was a lot of enthusiasm surrounding this vaccine because it only requires one shot and does not need to be stored at extremely cold temperatures.

Johnson & Johnson remained the world's most valuable biotech and pharmaceutical company in terms of market value as of 2022. Johnson & Johnson is a diversified healthcare corporation that owns well-known brands such as Band-Aid, Neutrogena, Tylenol, and Acuvue contact lenses through its over 250 subsidiaries. Over the last two decades, the company's employment has steadily increased. It announced the biggest number of employees to date by the end of 2022, hitting about 153 thousand.

Founded: 1886

Headquarters: Johnson and Johnson Plaza, New Brunswick, New Jersey, U.S.

Website: https://www.jnj.com/

Eli Lilly and Company was formed in the United States in 1876. As of now, the corporation employs over 39 thousand people worldwide. The company specializes in global health initiatives, diabetes care, and a variety of other human health items. Eli Lilly presently sells its products in over 120 countries around the world. As of 2021, the firm ranked among the top pharmaceutical corporations in terms of both prescription revenue and R&D spending.

Eli Lilly and Company has a strong presence in biotechnology. They are well-known for creating novel therapies and treatments for various diseases and medical problems, including cancer, diabetes, and autoimmune disorders.

Eli Lilly and Company has a significant presence in the biotechnology business and invests extensively in R&D to enhance its biotech product range. They have several biotech medicines on the market and developing, such as monoclonal antibodies, gene therapies, and other novel treatments. Furthermore, the company works with other biotech and pharmaceutical firms to develop new medicines and technologies.

Trulicity was Eli Lilly's largest revenue generator in 2022, accounting for around 7.4 billion US dollars. Verzenio was the next most profitable medicine, garnering approximately 2.4 billion US dollars.

Eli Lilly is the maker of several of the world's most popular diabetic prescription medicines and therapies. In terms of revenue, Eli Lilly was the second-largest seller of anti-diabetic drugs in 2017. Trulicity, one of Eli Lilly's main medications used to treat type II diabetes, is expected to be the top anti-diabetic pharmaceutical by 2024.

Founded: 1876

Headquarters: Indianapolis, Indiana, U.S.

Website: https://www.lilly.com/

It is quite rare for a company among the world's major pharmaceutical players to concentrate on just one medical problem. Novo Nordisk is one of these unusual companies, focusing nearly entirely on the development of diabetic medications and therapies. The company's headquarters are in a Copenhagen suburb. The Scandinavian country is a pharmaceutical powerhouse, especially given its small size. Novo Nordisk is arguably the most well-known Danish firm in the world and the country's second-largest in terms of sales, trailing only transportation and logistics behemoth Maersk.

Novo Nordisk will celebrate its 100th anniversary in 2023. From its inception in 1923, the Nordisk Insulinlaboratorium was dedicated to the treatment of diabetes and the production of insulin. Novo Nordisk was placed among the top ten worldwide pharma and biotech companies by market capitalization in late 2022. It is also the world's largest diabetic treatment firm. Diabetes treatment accounts for about four-fifths of the company's approximately $25 billion in global sales. Big names in this market include Eli Lilly, GlaxoSmithKline, Boehringer Ingelheim, and Sanofi.

The company's diabetes revenues are primarily produced by three product areas. Products based on glucagon-like peptide 1 (GLP-1) account for the most significant single share. Ozempic, a leading medicine from Novo Nordisk, is a GLP-1 receptor agonist that boosts insulin production. In 2022, Ozempic generated around $8.6 billion in revenue. Long-acting and fast-acting insulins are the other two product categories. NovoRapid/NovoLog is one of the more well-known fast-acting insulins, with over 2.2 billion US dollars in global sales.

Novo Nordisk's forecasts show a tremendous increase, although this is also owing to the global expansion and rising of diabetes. Diabetes is one of the most common diseases worldwide, claiming millions of lives yearly. The number of diabetics worldwide is anticipated to grow from 463 million to almost 700 million by 2045. As a result, the prevalence of diabetes among adults is expected to rise from 9.3 percent to over 11 percent. Total global costs to combat diabetes and its consequences are estimated at around 760 billion US dollars. China has about 120 million diabetics, making it the country with the greatest population in the world. As a result, Novo Nordisk's performance in the Chinese market is - and will be - critical.

Founded: 1923

Headquarters: Novo Allé, DK-2880, Bagsværd, Denmark

Website: https://www.novonordisk.com/

Merck & Co. is already a well-established top worldwide player in the pharmaceutical business, with about 60 billion US dollars in revenue. Merck & Co., Inc.'s origins can be traced back to the 17th century: Jacob Friedrich Merck founded the company in 1668 as a bought pharmacy store in Darmstadt, Germany. In 1891, a subsidiary called Merck & Co. was established in the United States. Merck & Co. has been an independent U.S. American firm since 1917 when it was commandeered by the US during World War I.

The company's offerings include vaccines, cancer treatments, and animal health items. Merck & Co. has one of the most approved pharmaceuticals as a firm, and it invests much in research and development. Diabetes, a chronic condition plagues society, is the goal of two of the company's most important medicines. Januvia (sitagliptin) is one of the most popular diabetes medications since it does not promote weight gain. In 2022, the medicine generated approximately 2.8 billion US dollars in sales. However, Merck's top product is the blockbuster cancer drug Keytruda.

Merck & Co. is a global corporation that generates more than half of its income outside of the United States. Merck & Co., one of the world's major pharmaceutical firms, with over 69,000 employees in 2022, scattered across 100 countries. In the same year, the company's total assets amounted to approximately 109 billion US dollars.

Merck is investing €250 million ($275.5 million) in a biotechnology development facility in Corsier-sur-Vevey, Switzerland. The facility will concentrate on the development of biotech medications as well as clinical study production. It is being built as a bridge between research and manufacturing of newly found drugs. In January 2020, the corporation performed a groundbreaking ceremony for the biotech development center. The facility's structural work was finished with a topping-out ceremony in July 2021. The next stage of its development will entail interior design and equipment installation, with the center set to open in 2023. The site is close to the company's current commercial biotech manufacturing facility in Corsier-sur-Vevey. It will consist of a structure with a total size of roughly 15,700m2 (168,993m2), with operations supported by around 250 personnel who are currently located in various places. The multidisciplinary team will aim to accelerate the availability of breakthrough biotech treatments for clinical trials.

Founded: 1891

Headquarters: Rahway, New Jersey, U.S.

Website: https://www.merck.com/

AbbVie is a biotech business focusing on pharmaceutical, biologic, and medical device research, development, and manufacturing. The company's primary emphasis is the discovery of medications to treat diseases such as cancer, immune-mediated diseases, neurological disorders, and chronic kidney disease.

AbbVie was created in 2013 as a spinoff from the healthcare corporation Abbott Laboratories. Since then, the company has grown tremendously and has established itself as a market leader in the biotech industry.

AbbVie's product portfolio includes some of the world's best-selling medications, including Humira, a treatment for autoimmune illnesses like rheumatoid arthritis, psoriasis, and Crohn's disease. In addition, the company has a pipeline of new medications in development that target a variety of ailments.

As of May 2023, AbbVie is a profitable firm with a market valuation of roughly $190 billion. In 2022, the company's revenue was $59.7 billion, with a net profit of $13.6 billion.

AbbVie is dedicated to being a good corporate citizen and has measures in place to promote sustainability, social responsibility, and ethical business practices. The corporation also participates in charitable efforts, emphasizing expanding access to healthcare and education.

AbbVie has a reputation for being a nice employer and has been named one of the top biotech firms to work for. The organization values diversity, inclusivity, and teamwork and offers its employees possibilities for personal and professional development.

Founded: 2013

Headquarters: North Chicago, Illinois, U.S.

Website: https://www.abbvie.com/

F. Hoffmann-La Roche AG, or Roche, is a Swiss global healthcare corporation that engages in various healthcare sectors, including pharmaceuticals, diagnostics, and biotechnology. The company's headquarters are in Basel. Roche has a substantial presence in biotech and is actively involved in biotechnology product research and development.

Roche creates and sells a wide range of medications and diagnostic items used in illness diagnosis, prevention, and treatment. The cancer medications Avastin, Herceptin, and Rituxan are among its most well-known products, as well as diagnostic tests for disorders such as HIV, hepatitis, and cancer.

Roche Pharma Research and Early Development (pRED) is a biotechnology division that focuses on the discovery and development of novel medications and cures utilizing biotechnology. The research efforts of pRED involve using genomics, proteomics, and other advanced technologies to identify novel drug targets and create new treatments for various diseases, including cancer, autoimmune disorders, and infectious diseases.

Roche is well-known for its dedication to innovation and heavy investment in research and development. Every year, the corporation invests billions of dollars in R&D, and its efforts have resulted in significant advancements in the field of healthcare.

Roche has a global workforce of over 100,000 individuals and works in more than 100 countries. The company has a significant presence in both developed and emerging areas and is dedicated to bringing its products and services to people all around the world.

Founded: 1896

Headquarters: Basel, Switzerland

Website: https://www.roche.com/

AstraZeneca plc is a global pharmaceutical and biotechnology company headquartered at the Cambridge Biomedical Campus in Cambridge, England. It is owned by the British and the Swedish governments. It has a portfolio of products for important illnesses in areas like oncology, cardiovascular, gastrointestinal, infection, neuroscience, respiratory, and inflammation. It helped make the COVID-19 vaccine that was created by Oxford and AstraZeneca.

In 1999, the Swedish Astra AB and the British Zeneca Group joined to form the company. The British Zeneca Group was created in 1993 when the pharmaceutical business of Imperial Chemical Industries was split into a separate company. Since the merger, it has become one of the biggest pharmaceutical companies in the world and has bought many other companies, including Cambridge Antibody Technology (2006), MedImmune (2007), Spirogen (2013), and Definiens (2014), which was bought by MedImmune. It does most of its research and development in three key places: Cambridge, England; Gothenburg, Sweden; and Gaithersburg, Maryland, in the United States.

AstraZeneca is listed on the London Stock Exchange as its main float and part of the FTSE 100 Index.

Founded: 1999

Headquarters: Cambridge, England, UK

Website: https://www.astrazeneca.com/

Novartis AG is a Swiss international biotechnology and pharmaceutical company headquartered in Basel, Switzerland (global research), and Cambridge, Massachusetts, United States. Novartis is one of the biggest pharmaceutical companies in the world. It is always in the top five, and it was the fourth-largest company by revenue in 2022.

Novartis manufactures the drugs clozapine (Clozaril), diclofenac (Voltaren; sold to GlaxoSmithKline in 2015 deal), carbamazepine (Tegretol), valsartan (Diovan), imatinib mesylate (Gleevec/Glivec), cyclosporine (Neoral/Sandimmune), letrozole (Femara), methylphenidate (Ritalin; production ceased 2020), terbinafine (Lamisil), deferasirox (Exjade), and others.

The companies Ciba-Geigy and Sandoz merged in March 1996 to make Novartis. The pharmaceutical and agrochemical businesses of both companies came together to make Novartis a separate company. Other Ciba-Geigy and Sandoz businesses were sold or split off into their own companies, like Ciba Specialty Chemicals. The Sandoz brand went away for three years, but it came back in 2003 when Novartis merged all of its generic drug businesses into one and called it Sandoz. Novartis sold its business in agrochemicals and genetically modified crops in 2000 when it spun off Syngenta with AstraZeneca. AstraZeneca also sold its business in agrochemicals.

Novartis is a full member of the Pharmaceutical Research and Manufacturers of America (PhRMA), the International Federation of Pharmaceutical Manufacturers and Associations (IFPMA), and the European Federation of Pharmaceutical Industries and Associations (EFPIA).

Founded: 1996

Headquarters: Basel, Switzerland

Website: https://www.novartis.com/

Pfizer Inc. is a multinational pharmaceutical and biotechnology firm headquartered in Manhattan, New York City, at The Spiral. In 1849, two German entrepreneurs, Charles Pfizer (1824-1906) and his cousin Charles F. Erhart (1821-1891), founded the corporation in New York.

Pfizer develops and manufactures immunology, oncology, cardiology, endocrinology, and neurology drugs and vaccines. The Pfizer-BioNTech COVID-19 vaccine ($37 billion in 2022 revenues), Nirmatrelvir/ritonavir ($18 billion in 2022 revenues), Apixaban ($6 billion in 2022 revenues), a pneumococcal conjugate vaccine ($6 billion in 2022 revenues), and Palbociclib ($5 billion in 2022 revenues) are the company's most profitable products. In 2022, the United States accounted for 42% of the company's revenues, Japan accounted for 8%, and other countries accounted for 50%.

From 2004 to August 2020, Pfizer was a component of the Dow Jones Industrial Average stock market index. The company is ranked 43 on the Fortune 500 and 43 on the Forbes Global 2000.

Founded: 1849

Headquarters: The Spiral, New York City, USA

Website: https://www.pfizer.com/

Thermo Fisher Scientific is a worldwide corporation involved in many areas, including life sciences, healthcare, diagnostics, and analytical instruments. Thermo Fisher Scientific is a significant company in the biotechnology business.

Thermo Fisher Scientific provides a comprehensive range of biotechnology research and development products and services, including genomic sequencing, gene editing, protein analysis, cell culture, and other biotech-related applications. Biotech businesses, academic research institutes, and government agencies use the company's products to further scientific discoveries and improve human health.

Biotech-related goods and services constitute an essential component of Thermo Fisher Scientific's total business, and the company has made strategic acquisitions to increase its footprint in the biotech industry.

With more than $40 billion in annual revenue, Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in science service. Their mission is to help customers make the world healthier, cleaner, and safer. They are here to help customers advance life sciences research, address challenging analytical challenges, enhance laboratory productivity, improve patient health through diagnostics, or develop and manufacture life-changing treatments.

Through industry-leading brands such as Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon, and PPD, their global team provides an unrivaled combination of innovative technologies, purchasing convenience, and pharmaceutical services.

Founded: 2016

Headquarters: Waltham, Middlesex County, Massachusetts, USA

Website: https://www.thermofisher.com/