Johnson & Johnson, a leading pharmaceutical, medical device, and consumer packaged products manufacturer was established in 1886 in New Brunswick, New Jersey. With a total sales figure of 94.9 billion USD in 2022, it holds a significant position in the global market. The corporation operates across three main segments: medical devices and diagnostics, pharmaceuticals, and consumer packaged goods. Notably, the consumer packaged goods segment contributed 15 billion USD to the company's global revenue in 2022.

Johnson & Johnson's pharmaceutical business has experienced substantial growth in recent years, representing approximately 55 percent of its total sales. The company focuses on key therapeutic areas, including immunology, oncology, infectious diseases, and vaccinations. In February 2021, Johnson & Johnson sought emergency use permission from the FDA (U.S. Food and Drug Administration) for its COVID-19 vaccine, generating significant interest due to its single-shot administration and non-demanding storage requirements.

As of 2022, Johnson & Johnson retains its position as the world's most valuable biotech and pharmaceutical company in terms of market value. Diversified as a healthcare corporation, it owns renowned brands such as Band-Aid, Neutrogena, Tylenol, and Acuvue contact lenses through its extensive network of over 250 subsidiaries. Over the past two decades, the company has consistently increased its workforce, reaching a record high of approximately 153,000 employees by the end of 2022.

Founded: 1886
Headquarters: Johnson and Johnson Plaza, New Brunswick, New Jersey, U.S.
Website: https://www.jnj.com/

Eli Lilly and Company, established in the United States in 1876, boasts a global workforce of over 39,000 employees. Specializing in global health initiatives and diabetes care, the company offers a diverse range of human health products. With a presence in more than 120 countries, Eli Lilly has established itself as a prominent player in the pharmaceutical industry, ranking among the top companies in prescription revenue and research and development (R&D) expenditure in 2021.

Recognized for their contributions to biotechnology, Eli Lilly and Company is renowned for pioneering innovative therapies and treatments for various diseases, including cancer, diabetes, and autoimmune disorders.

Investing significantly in R&D to expand its biotech product portfolio, Eli Lilly actively develops and markets a range of biotech medicines, such as monoclonal antibodies, gene therapies, and other groundbreaking treatments. Additionally, the company collaborates with other biotech and pharmaceutical firms to drive the development of new medicines and technologies.

In 2022, Trulicity emerged as Eli Lilly's top revenue-generating product, earning approximately 7.4 billion USD. Following closely, Verzenio achieved significant profitability, generating around 2.4 billion USD in sales.

Eli Lilly stands as a prominent manufacturer of leading prescription medicines and therapies for diabetes. In 2017, the company ranked as the second-largest seller of anti-diabetic drugs based on revenue. Trulicity, one of Eli Lilly's key medications for type II diabetes treatment, is projected to become the leading anti-diabetic pharmaceutical by 2024.

Founded: 1876
Headquarters: Indianapolis, Indiana, U.S.
Website: https://www.lilly.com/

Merck & Co., a leading player in the global pharmaceutical industry, has achieved substantial revenue of approximately 60 billion USD. The company traces its origins back to 1668 when Jacob Friedrich Merck established a pharmacy store in Darmstadt, Germany. In 1891, a subsidiary known as Merck & Co. was established in the United States, and since 1917, it has operated as an independent American firm.

Merck & Co. offers a wide range of products, including vaccines, cancer treatments, and animal health solutions. Renowned for its extensive portfolio of approved pharmaceuticals, the company prioritizes research and development. Notably, it focuses on addressing diabetes, a prevalent chronic condition, with two significant medications. Januvia (sitagliptin) is a popular diabetes drug due to its weight-neutral effects and generated approximately 2.8 billion USD in sales in 2022. However, Merck's flagship product is the blockbuster cancer drug Keytruda.

Merck & Co. generates over half of its revenue outside the United States as a global corporation. With a workforce of over 69,000 employees in 2022, spread across 100 countries, it stands as one of the major pharmaceutical companies worldwide. Additionally, the company's total assets reached approximately 109 billion USD in the same year.

Merck is making a substantial investment of €250 million ($275.5 million) in a biotechnology development facility in Corsier-sur-Vevey, Switzerland. This facility will focus on developing biotech medications and clinical trial production, serving as a crucial link between research and manufacturing of newly discovered drugs. The groundbreaking ceremony for the biotech development center took place in January 2020, and the facility's structural work was completed with a topping-out ceremony in July 2021. The next phase involves interior design and equipment installation, with the center scheduled to open in 2023. The facility, situated near Merck's existing commercial biotech manufacturing facility in Corsier-sur-Vevey, spans approximately 15,700m2 and will be supported by around 250 personnel. This multidisciplinary team aims to expedite the availability of groundbreaking biotech treatments for clinical trials.

Founded: 1891
Headquarters: Rahway, New Jersey, U.S.
Website: https://www.merck.com/

AbbVie is a leading biotech company specializing in the research, development, and manufacturing of pharmaceuticals, biologics, and medical devices. The company's primary focus lies in discovering innovative treatments for diseases such as cancer, immune-mediated disorders, neurological conditions, and chronic kidney disease.

Established in 2013 as a spinoff from Abbott Laboratories, AbbVie has experienced remarkable growth and established itself as a prominent player in the biotech industry.

AbbVie's product portfolio includes globally renowned medications, with Humira being a standout treatment for autoimmune conditions like rheumatoid arthritis, psoriasis, and Crohn's disease. Additionally, the company maintains a robust pipeline of new medications under development, targeting various ailments.

As of May 2023, AbbVie demonstrates financial success, with a market valuation of approximately $190 billion. In 2022, the company achieved a revenue of $59.7 billion, resulting in a net profit of $13.6 billion.

AbbVie is committed to corporate citizenship, prioritizing sustainability, social responsibility, and ethical business practices. The company actively engages in charitable initiatives, with a particular focus on improving access to healthcare and education.

Recognized as an exceptional employer, AbbVie has been named one of the top biotech firms to work for. The organization values diversity, inclusivity, and teamwork, offering its employees opportunities for personal and professional growth.

Founded: 2013
Headquarters: North Chicago, Illinois, U.S.
Website: https://www.abbvie.com/

Pfizer Inc., a renowned multinational pharmaceutical and biotechnology company, is headquartered in Manhattan, New York City, specifically at The Spiral. The corporation was founded in New York in 1849 by German entrepreneurs Charles Pfizer (1824-1906) and Charles F. Erhart (1821-1891).

Pfizer specializes in the development and manufacturing of drugs and vaccines in various therapeutic areas, including immunology, oncology, cardiology, endocrinology, and neurology. The company's most profitable products in 2022 include the Pfizer-BioNTech COVID-19 vaccine ($37 billion in revenues), Nirmatrelvir/ritonavir ($18 billion in revenues), Apixaban ($6 billion in revenues), a pneumococcal conjugate vaccine ($6 billion in revenues), and Palbociclib ($5 billion in revenues). The United States accounted for 42% of Pfizer's revenues, while Japan contributed 8%, with the remaining 50% attributed to other countries.

Pfizer was a component of the Dow Jones Industrial Average stock market index from 2004 to August 2020. The company holds a prominent position in both the Fortune 500 and the Forbes Global 2000, ranking 43rd in both lists.

Thermo Fisher Scientific is a global corporation with a strong presence in various sectors, including life sciences, healthcare, diagnostics, and analytical instruments. It holds a significant position in the biotechnology industry.

Thermo Fisher Scientific offers a wide range of products and services for biotechnology research and development. These include genomic sequencing, gene editing, protein analysis, cell culture, and biotech applications. The company's products are utilized by biotech companies, academic research institutes, and government agencies to drive scientific discoveries and improve human health.

Biotech-related offerings are crucial to Thermo Fisher Scientific's overall business strategy. The company has strategically acquired other entities to expand its presence in the biotech industry.

Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in science service and generates over $40 billion in annual revenue. Their mission revolves around assisting customers in creating a healthier, cleaner, and safer world. Whether advancing life sciences research, tackling complex analytical challenges, boosting laboratory productivity, enhancing patient health through diagnostics, or developing and manufacturing life-changing treatments, Thermo Fisher Scientific is dedicated to providing the necessary support.

With industry-leading brands such as Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon, and PPD, the company's global team offers an unmatched combination of innovative technologies, convenient purchasing options, and pharmaceutical services.

Founded: 2016
Headquarters: Waltham, Middlesex County, Massachusetts, USA
Website: https://www.thermofisher.com/

Bristol-Myers Squibb Company (BMS) is a renowned American multinational pharmaceutical company headquartered in New York City. It holds a prominent position among the world's largest pharmaceutical companies and consistently appears on the prestigious Fortune 500 list of the largest U.S. corporations. In fiscal 2022, BMS achieved an impressive total revenue of $46.2 billion.

At Bristol Myers Squibb, the focus lies on the production of prescription pharmaceuticals and biologics across multiple therapeutic areas. These encompass crucial fields such as cancer, HIV/AIDS, cardiovascular disease, diabetes, hepatitis, rheumatoid arthritis, and psychiatric disorders.

The company's primary research and development (R&D) facilities are strategically situated in Lawrence, New Jersey (formerly Squibb, near Princeton), Summit, New Jersey (previously the headquarters of Celgene), New Brunswick, New Jersey, Redwood City, California, and Seville, Spain. In addition to these sites, BMS maintains a presence in Devens and Cambridge, Massachusetts, East Syracuse, New York, Braine-l'Alleud, Belgium, Tokyo, Japan, Bangalore, India, and Wirral, United Kingdom. It is worth noting that Bristol-Myers previously operated an R&D site in Wallingford, Connecticut.

Bristol-Myers Squibb's extensive R&D network underscores its commitment to innovation and scientific advancement in the pharmaceutical industry. The company strives to develop groundbreaking treatments and therapies that can positively impact global healthcare through these strategically located facilities.

Founded: 1887

Headquarters: New York City, New York, U.S.

Website: https://www.bms.com/

Amgen Inc., formerly known as Applied Molecular Genetics Inc., is a leading American multinational biopharmaceutical company located in Thousand Oaks, California. Founded in 1980, Amgen is one of the world's largest independent biotechnology companies that focuses on molecular biology and biochemistry to provide healthcare based on recombinant DNA technology.

The company's primary goal is to develop innovative medicines that treat serious illnesses, such as cancer, cardiovascular disease, and bone diseases. Some of Amgen's most successful products include Neulasta, used to prevent infections in patients undergoing cancer chemotherapy, and Enbrel, a tumor necrosis factor blocker that treats autoimmune diseases like rheumatoid arthritis.

Amgen is a major contributor to the Thousand Oaks community, with its headquarters employing over 5,000 people and making up 7.5% of the city's total employment. The company also sponsors the Tour of California, one of the largest professional cycling events in North America.

Founded: 1980

Headquarters: Thousand Oaks, California, U.S.

Website: https://www.amgen.com/

Gilead Sciences, Inc., headquartered in Foster City, California, is an esteemed American biopharmaceutical company specializing in developing antiviral drugs. These drugs play a crucial role in treating a range of diseases, including HIV/AIDS, hepatitis B, hepatitis C, influenza, and COVID-19. Notable medications developed by Gilead include ledipasvir/sofosbuvir and sofosbuvir.

Gilead Sciences is recognized as a key player in the biopharmaceutical industry and is listed on both the NASDAQ Biotechnology Index and the S&P 500. The company was established in 1987 by Michael L. Riordan. It was initially known as Oligogen, a name inspired by oligomers, which are small DNA strands used to target specific genetic sequences.

Over the years, Gilead achieved significant milestones. It conducted a successful IPO in 1992 and made substantial progress in drug development, with notable products like Tamiflu and Vistide emerging during that decade. In the 2000s, Gilead gained approval for drugs such as Viread and Hepsera, marking its transition from a biotechnology company to a pharmaceutical company. Along the way, the company acquired various subsidiaries while maintaining reliance on contract manufacturing for its drugs.

During the 2010s, Gilead Sciences continued its growth trajectory. However, it faced scrutiny over its business practices, particularly concerning the pricing of drugs like Sovaldi and Truvada in the United States, which were deemed excessively high compared to production costs and prices in the developing world. Despite these challenges, Gilead Sciences remains committed to advancing healthcare and developing innovative treatments to improve patients' lives.

Founded: 1987

Headquarters: Foster City, California, United States

Website: https://www.gilead.com/

Vertex Pharmaceuticals, headquartered in Boston, Massachusetts, is a highly regarded biopharmaceutical company that has garnered global recognition for its exceptional contributions to the field of biotechnology. By focusing on pioneering research and development, Vertex strives to make a meaningful impact on the lives of patients facing serious illnesses.

At the core of Vertex Pharmaceuticals' success lies its impressive lineup of products. The company has developed a portfolio of groundbreaking medications that have revolutionized the treatment landscape for various conditions. Among its flagship therapies are Symdeko, Orkambi, and Kalydeco, which offer targeted solutions for individuals suffering from cystic fibrosis. These innovative treatments have demonstrated remarkable efficacy in addressing the root cause of the disease, providing new hope and improved quality of life for patients.

Vertex Pharmaceuticals' exceptional performance and unwavering commitment to innovation have solidified its position as a leader in the biotechnology industry. The company's relentless dedication to scientific research and development has led to significant advancements in the field. Vertex continually explores new frontiers and potential treatments for complex diseases by prioritizing precision medicine and genetic therapies.

Founded: 1989

Headquarters: Boston, Massachusetts, U.S.

Website: https://www.vrtx.com/