Alexander the Great had two distinct eye colors

Alexander the Great, one of the most influential individuals in ancient times, had two distinct eye colors. Heterochromia iridium is the name of the disorder that Alexander the Great had that resulted in his having two distinct colored eyes. Several well-known people have this illness, despite the fact that it is actually not that prevalent in humans. Kate Bosworth, Wentworth Miller, Mila Kunis, Henry Cavill, and Kiefer Sutherland. However, it is not unusual for celebrities to suffer from eye issues. Even a well-known performer from the entertainment field nowadays is blind in one eye. Although it is uncommon and does occasionally happen, this illness can be seen in a variety of animals, most notably numerous pets.

A deficiency or overabundance of melanin in the iris of one of the eyes accounts for the difference in eye color between Alexander the Great and celebrities like Mila Kunis. The majority of scientists agree that the main reason for heterochromia, at least in domestic animals, is a lack of genetic variety, despite the fact that many other theories have also been put up. This is brought on by mutations in the 8-HTP pathway's melanin distribution-determining genes, which are typically only disrupted by chromosomal homogeneity. Heterochromia is not related to polymorphism and is uncommon in humans, affecting less than 200,000 people in the United States, but is frequent in some kinds of cats, dogs, cattle, and horses due to inbreeding. genetic shape. Either the afflicted eye is hyper- or hypopigmented. Humans who produce more melanin in their eyes have hyperplasia of the iris tissues, whereas those who produce less melanin have hypoplasia.