Anne Frank was treated for anxiety and depression

As her stay in the Secret Annex became longer, Anne Frank's disposition changed from being a cheerful, lively, chatty, perky, amusing girl to being gloomy, self-critical, and depressed. The same person who could express her thoughts of utter anguish in such lovely prose while writing about birthday poetry, girlfriends, and royal genealogical charts.

Anne wrote on October 29, 1943: "Outside, you don't hear a single bird, and a deathly, oppressive silence hangs over the house and clings to me as if it were going to drag me into the deepest regions of the underworld... I wander from room to room, climb up and down the stairs and feel like a songbird whose wings have been ripped off and who keeps hurling itself against the bars of its dark cage."

Anne had started to feel down. On September 16, 1943, Anne acknowledged that she had begun using valerian drops for her despair and anxiety. Anne was still gloomy and had lost her appetite the next month. Brewer's yeast, dextrose, cod liver oil, and calcium have been "plied" on Anne, according to her relatives. The only way to truly alleviate Anne's despair was to set her free from her imprisonment, but this was an unattainable remedy.