Common and Serious Side Effects of Buprenorphine

These are not the only buprenorphine side effects. Patients should speak with their doctor or pharmacist for more information. Patients should notify their healthcare provider if any side effects are bothersome or do not go away.

All side effects should be reported online to MEDWatch, the FDA's medical product safety reporting program for healthcare professionals, patients, and consumers, or by calling 1-800-FDA-1088.

Common side effects of buprenorphine include:

• Constipation, headache, nausea, and vomiting
• Dizziness
• Drowsiness and fatigue
• Sweating
• Dry mouth
• Tooth decay
• Muscle aches and cramps
• Inability to sleep
• Fever
• Blurred vision or dilated pupils
• Tremors
• Palpitations
• Disturbance in attention

Serious side effects of buprenorphine include:

• Respiratory distress
• Overdose
• Adrenal insufficiency
• Dependence
• Withdrawal
• Itching, pain, swelling, and nerve damage (implant)
• Pain at injection site (injection)
• Neonatal abstinence syndrome (in newborns)