He played his guitar upside down

Jimi Hendrix possessed a left hand. He just flipped the guitar over and put the strings back in the right sequence when he bought his first guitar. The top cutaway was now at the bottom, and the reverse was true. This is not ergonomically sound with Hendrix's Fender Stratocaster (and other guitars), as your hand loses space to reach the higher frets. This is one of the interesting facts about Jimi Hendrix.

Consider that for a moment. The majority of guitarists spend hours simply considering which instrument is the coziest for them and how to play as easily as possible. It is practically insane to use a right-handed guitar body on a left-handed player, or vice versa. The best guitar ever did exactly that, but it did not stop him from becoming such a legend.

Left-handedness was a trait of Jimi Hendrix. When he first got a guitar, he just rearranged the strings, so everything else on the instrument—aside from the strings—was backward. This was not ergonomically proper for the Fender Stratocaster guitar he was playing or for the majority of other guitars because the hand lost space to reach the top frets.

Since many guitarists spend a lot of time considering which guitar is ideal for them and most comfortable to make the playing experience as seamless as possible, it is practically difficult for a left-handed person to play a right-handed guitar or vice versa. Hendrix, on the other hand, chose not to go down that road since he did the opposite of what was expected and was still able to excel in the same field.