His children almost have an unfavorable life
Henry Clay Sr. and his wife Lucretia Hart had 11 children together shortly after being married, with 6 daughters and 5 sons. By 1835, all six of his daughters had passed away from various ailments, including problems during childbirth and yellow fever. All of his daughters had passed away before them.
However, one of his sons lost his life during the American War in Mexico's Battle of Buena Vista. Theodore Wythe Clay, the oldest son of Clay, spent the latter half of his life behind bars at a mental institution. Theodore suffered a head injury as a toddler from a strike that fractured his skull. As he aged, his health worsened, and he was committed to an asylum in Lexington from 1831 until he died in 1870.
Thomas (who served prison time in Philadelphia in 1829–1830) became a successful farmer, James established a legal practice (and later served in Congress), and John (who was in his mid-20s) (age was also confined to the refugee camp for a short time) became a successful horse breeder.
Finally, it was Lexington Cemetery after his wife passed away at the age of 83. They are the great-grandparents of John C. Breckinridge, an American statesman who served as President James Buchanan's vice president.