How Jardiance works

Jardiance (empagliflozin) works by inhibiting the sodium-glucose co-transporter 2 (SGLT2), a protein found in the early proximal tubule of a nephron (a kidney cell) that is responsible for the reabsorption of glucose back into circulation from the blood that flows through the kidneys (the glomerular filtrate). Empagliflozin prevents glucose resorption and increases the amount of glucose excreted in the urine by blocking this transporter.