Interactions
Medicines that interact with benzonatate may reduce its effect, shorten its duration of action, increase side effects, or have no effect when combined. An interaction between two medications does not always necessitate the discontinuation of one of them; however, it can. Consult your doctor about how to handle drug interactions.
There are no known significant interactions between benzonatate and other drugs. However, because it causes constipation, sedation, and nausea, interactions with the following drugs are possible:
- other medications that cause constipation, such as ondansetron, opioids, or iron supplements
any medication that may cause drowsiness, such as amphetamines, azelastine, benzodiazepines (eg, diazepam, lorazepam), first-generation antihistamines (such as doxylamine or promethazine), metoclopramide, or opioids (such as hydrocodone, morphine) - other medications that may also upset the gastrointestinal tract, such as prednisone or NSAIDs (such as ibuprofen or naproxen).
While taking benzonatate, avoid drinking alcohol or using illegal or recreational drugs.
For a complete list of interactions, consult the benzonatate prescribing information.
