Interactions

Medicines that interact with Benadryl may reduce its effect, shorten its duration of action, increase side effects, or have no effect when combined. An interaction between two medications does not always necessitate the discontinuation of one of them; however, it can. Consult your doctor about how to handle drug interactions.

Benadryl may interact with the following medications:

• benzodiazepines, such as diazepam, oxazepam, and temazepam
• monoamine oxidase inhibitors, such as isocarboxazid, selegiline, or tranylcypromine
• opioids, such as oxycodone, morphine, or codeine
• sedatives, or any medication that causes sedation, such as sleeping pills, muscle relaxants, or antidepressants
• other medications that contain diphenhydramine, such as creams and gels
• other medications used to treat allergies.

Benadryl's sedative effects may be exacerbated by alcohol.

Please keep in mind that this list is not exhaustive and only includes common medications that may interact with Benadryl. For a complete list of interactions, consult the Benadryl prescribing information.