Interactions

Medicines that interact with Bunavail may reduce its effect, shorten its duration of action, increase side effects, or have no effect when combined. An interaction between two medications does not always necessitate the discontinuation of one of them; however, it can. Consult your doctor about how to handle drug interactions.

Bunavail may interact with the following medications:

• 5-hydroxytryptophan
• albuterol
• antibiotics, such as azithromycin, clarithromycin, erythromycin, and norfloxacin
• antidepressants, such as tricyclic antidepressants (eg, amitriptyline), monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine), or SSRIs (eg, fluoxetine, sertraline)
• antifungal agents, such as itraconazole and ketoconazole
• anticonvulsants, such as brivaracetam, carbamazepine, divalproex, lamotrigine, phenytoin, phenobarbital, or primidone
• antipsychotics (such as butyrophenones, phenothiazines, or thioxanthenes) and atypical antipsychotics (eg, aripiprazole, olanzapine, quetiapine, ziprasidone)
• any medication that may cause drowsiness, such as benzodiazepines (eg, alprazolam, diazepam, lorazepam), sleeping pills (such as zolpidem or ziprasidone), or first-generation antihistamines (such as doxylamine or promethazine)
• bisacodyl
• bupropion
• buspirone
• busulfan
• cannabis
• cyclosporine
• dapsone
• dasatinib
• droperidol
• echinacea
• flucloxacillin
• heart medications such as amlodipine, atenolol, or candesartan
• HIV medications, such as delavirdine or ritonavir
• metoclopramide
• muscle relaxants, such as baclofen or cyclobenzaprine
• opioids such as codeine, fentanyl, or morphine
• pregabalin
• rifampin
• sodium oxybate
• valerian
• other medications that affect serotonin, such as amphetamines, lithium, tramadol, or triptans (eg, almotriptan, eletriptan, or sumatriptan).

While taking Bunavail, avoid grapefruit products, alcohol, and illegal or recreational drugs.

It should be noted that this list is not exhaustive and only includes common medications that may interact with Bunavail. For a complete list of interactions with Bunavail, consult the prescribing information.