Interactions

Medicines that interact with clonazepam may reduce its effect, shorten its duration of action, increase side effects, or have no effect when combined. An interaction between two medications does not always necessitate the discontinuation of one of them; however, it can. Consult your doctor about how to handle drug interactions.

Clonazepam may interact with the following medications:

• anti-anxiety medications, including other benzodiazepines, such as diazepam and oxazepam
• anticonvulsants such as phenytoin
• antidepressants, such as amitriptyline, imipramine, nortriptyline
• antihistamines that cause sedation, such as diphenhydramine
• duloxetine
• monoamine oxidase inhibitors, such as selegiline, isocarboxazid, or phenelzine
• opioid analgesics such as oxycodone and morphine
• muscle relaxants such as cyclobenzaprine
• sleeping pills, such as zolpidem
• some chemotherapy treatments
• some medications used to treat mental illness, such as clozapine and thioridazine.

Clonazepam side effects such as drowsiness and dizziness may be exacerbated by alcohol.

It should be noted that this list is not exhaustive and only includes common medications that may interact with clonazepam. For a complete list of interactions with clonazepam, consult the prescribing information.