It's Easy To Unintentionally Consume Too Much
The FDA has established a 4,000 mg daily maximum for adults. Contrary to popular belief, it's far simpler to exceed this dosage—one Extra Strength Tylenol gel pill, for instance, carries 500mg. Acetaminophen overdose can cause liver failure or even death. According to the National Institutes of Health, overdoses of the popular pain reliever are among the most frequent poisonings in the world. The cause of hepatotoxicity when using Acetaminophen overdose is because when the drug is taken orally, the drug will be absorbed into the blood and metabolized by the liver in many forms, of which about 4% is converted into N-acetyl benzoquinoneimine - a harmful substance. for the liver. Therefore, the amount of Acetaminophen is too large, leading to a lack of glutathione to respond, causing toxic substances in the liver to accumulate, causing harm to the liver. Acetaminophen is also recommended for pregnant women, if used in excess, it can be dangerous to the fetus because this drug can penetrate through the placenta. In the case of the elderly, if using the drug for a long time, it may cause fatigue because Acetaminophen loses hemoglobin carrying oxygen in the blood. In addition, a study by the US Food and Drug Administration (FDA) said that the use of Acetaminophen can cause some harmful complications for the skin such as peeling, epidermal necrosis.
The FDA updated its labeling guidelines for medication makers in April 2009. Acetaminophen must be clearly identified as the active component on any product's display panel, and customers must be alerted to the risk of liver poisoning. The FDA advises consumers to take acetaminophen-containing medications only as directed and to refrain from consuming more than one acetaminophen product at a time.
