Izumi Curtis
Izumi Curtis, one of the best teacher characters in anime of all time, is a master alchemist and talented martial artist who lives in the southern Amestrian village of Dublith with her husband Sig. Though she normally does not accept students, she agreed to take on Edward and Alphonse Elric as apprentices and educated them in both alchemical theory and martial skills for six months. Izumi eventually grew to love them as much as she loved her own children, and she became a long-term source of advice and support for the Elrics' future venture.
Izumi frequently takes obvious satisfaction in introducing herself as a "simple, kind housewife" to anyone who asks. Izumi Curtis, Edward and Alphonse Elric's tough-as-nails teacher, is a skilled alchemist who can compete with state alchemists like Roy Mustang and Solf J. Kimblee. She taught the Elric brothers almost everything they know about battle and alchemy.
Many people regard Izumi Curtis as an invincible paragon of terrible might and talent in Alchemy, yet his most powerful acts are followed by a painful reflux of blood caused by an inside injury from a failed Human Transmutation several years prior. Edward was able to become a state alchemist at the age of 12 thanks to her lessons and innate ability. Even as they grew older and stronger, Edward and Alphonse learned a lot from her and admired her tremendously. Izumi may be harsh on them, yet she adores them as if they were her own children.
Anime: Fullmetal Alchemist: Brotherhood