Kevzara interactions

When combined with Kevzara, drugs that interact with it either lessen its effect, shorten its duration of action, exacerbate side effects, or have no effect at all. Even though it is not always necessary to stop taking one of the drugs, sometimes there is an interaction between two drugs. Consult your doctor to learn how to handle drug interactions.

Typical drugs with which Kevzara may interact are as follows:

• aminophylline
• anticonvulsants, such as phenobarbital or phenytoin
• antipsychotics, such as clozapine
  
• benzodiazepines, such as alprazolam or clonazepam
• corticosteroids (such as prednisone or dexamethasone)
• heart medications such as amiodarone or flecainide
• herbals, such as echinacea or black cohosh
• hormones such as levonorgestrel or norgestrel
• immunosuppressants such as azathioprine, cyclosporine, or tacrolimus
• live vaccines and some other vaccines, such as BCG, cholera, measles, hepatitis b vaccines, yellow fever, or live influenza vaccines
• methotrexate
• opioids, such as fentanyl or oxycodone
• other biologics, such as adalimumab, etanercept, golimumab, or infliximab
• probiotics, such as lactobacillus
• statins, such as atorvastatin or simvastatinn
• theophylline
• warfarin
• zinc.

Any medication that is metabolized by CYP450 enzymes, particularly those with a narrow therapeutic index (such as cyclosporine or warfarin), has the potential to interact with Kevzara. This is because increased levels of certain cytokines (such as IL-1, IL-6, IL-10, and IL-17) during chronic inflammation can alter the formation of CYP450 enzymes. Because Kevzara prevents IL-6 from interacting with the IL-6 receptor, it may restore CYP450 enzyme formation. Keep an eye out for any changes in effect and consider any dosage changes.

It should be noted that this list is not exhaustive and only includes common medications that may interact with Kevzara. For a complete list of interactions with Kevzara, consult the prescribing information.