Lake Tahoe
One of California's most picturesque routes is Route 395. Along the journey, stop in the little communities of Lone Pine, Big Pine, and Bishop for charming strolls and delectable side trips (try Copper Top BBQ in Big Pine and the renowned Schat's Bakery in Bishop). The region is ideal for exploring by automobile; pick any road heading west to ascend into the mountains, where you'll find pine forests, glacial lakes with pristine clarity, and little settlements. To relieve sore muscles following a hard day of driving, ask the locals where to find one of the many natural hot springs.
You can also stop at one of the world-famous bouldering and climbing locations like the Happys, Sads, or Owens River Gorge. Mono Lake's "tufas," slender spires of accumulated limestone, reflect over the salty waters, creating unearthly waterscapes. A visit to Yosemite National Park and a hike or stroll (or ski day) in Mammoth are essentials if you have the time. Bodie, one of the most real and well-preserved ghost towns in America, is another excellent (though lengthy) side trip.
Miles from L.A.: ~465
Suggested round trip time: 4–5 days min
Location: Sierra Nevada Mountains