Muscle Breakdown
Damaged muscle fibers enter the circulation in the dangerous disease known as rhabdomyolysis, which can result in kidney failure and other issues. Rhabdomyolysis is frequently brought on by trauma, infection, drug use, muscular tension, and insect or snake bites that are very toxic.
Several reports of rhabdomyolysis linked to high caffeine use have also been reported, though this is rather uncommon. After consuming 32 ounces (1 liter) of coffee with around 565 mg of caffeine, a woman in one example had nausea, vomiting, and dark urine. Thankfully, after receiving treatment from medication and fluids, she made a full recovery. Importantly, this is a large dosage of caffeine to consume within a short period of time, especially for someone who isn't used to it or who is extremely sensitive to its effects.