Response and effectiveness
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It could take up to two hours for absorption to occur. Peak concentrations are reached six hours after administration. Full clinical effects (such as relief from depression, anxiety, or pain) may take several weeks to manifest.
60mg of Cymbalta is as effective as 120mg for some conditions (such as diabetic peripheral neuropathy), with fewer side effects.
Dosages greater than 60mg per day are generally associated with more side effects.