Saint Louis, Missouri

Saint Louis, Missouri, is one of the smallest large cities on this list, with a population of just over 300,000 people. The cost of living in Louis is 19 percent less than the national average and roughly 5% less than the Missouri state average. When compared to many other parts of the state, those coming to St. Louis should expect to pay less for healthcare, housing, and utilities. Food and local transit expenditures are also on the upper end of the scale.

Saint Louis was acquired by Thomas Jefferson as part of the Louisiana Purchase, and it was also the starting point for Lewis and Clark's expedition in 1804. This rich history has resulted in a plethora of historic museums and structures, many of which are open to the public and free of charge. With a typical property price of $244,787, Saint Louis is an appealing spot to settle down.