Theodora
Theodora was not born into high society like the others on this list. Her mother was an actress, while her father was a bear trainer. Theodora may have performed as a prostitute and followed her mother onto the stage. After leaving her dubious occupations, Justinian, the heir to the throne, caught her attention. Despite obstacles with the law and opposition from the imperial family, they managed to win his love and get married. Theodora was a dominant figure in court when her husband was emperor. The Byzantine Empire was ruled by Justinian I and Theodora in the sixth century. The Empire had prosperity, illumination, and expansion.
Theodora persuaded people to stay and fight when riots threatened to topple Justinian instead of running away. Her followers attained positions of tremendous influence. Theodora was the first female figure to acknowledge the rights of women and make changes to the legal system. She was revered as a saint by the Eastern and Oriental Orthodox Churches and advocated for social and theological causes.
She similarly gave political assistance and guidance to Jacob Baradaeus's Ministry. Sadly, she passed away on June 28th, 548, from cancer and became one of the most powerful women of Ancient Rome. The Church of Holy Apostles, a structure created by Theodora and Justinian, is where her remains were interred.