What Other Medications May Interact With Buspirone?

Do not take buspirone if you have recently taken a monoamine oxidase inhibitor (MAOI) such as phenelzine (Nardil®), isocarboxazid (Marplan®), selegiline (Eldepryl®, EMSAM®), or tranylcypromine (Parnate®). The combination of buspirone and these agents can result in a significant increase in blood pressure.


The following medications may increase buspirone levels and effects:

  • Diltiazem (Cardizem®, Dilacor®, Tiazac®)
  • Verapamil (Calan®, Covera-HS®, Isoptin®, Verelan®)
  • Erythromycin (E-Mycin®, E.E.S.®, Ery-Tab®, Eryc®, others)
  • Consuming large amounts of grapefruit juice can increase the amount of buspirone in your blood

The following medications may decrease the levels and effects of buspirone:

  • Rifampin (Rifadin®, Rimactane®, Rifampicin®, others)
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