Wren passed away at the age of 91

Wren spent his remaining five years in his residence at Hampton Court after retiring there in 1718 at the age of 86. He frequently traveled to London to make unannounced trips to St. Paul's to check on the status of "my greatest achievement." At the age of 90, he went to London on one of these journeys and came down with a chill that got worse over the next three days. Wren passed away on February 25, 1723, when a servant attempted to rouse him from his siesta.

On March 5, 1723, Wren was buried. His corpse was positioned in the southeast corner of St. Paul's crypt. Along with memorials for his daughter Jane, sister Susan Holder, and her husband William, he is remembered in the crypt of St. Paul's Cathedral. He has an intriguing inscription on his tombstone. Although it is written in Latin, it may be translated as "If you seek his remembrance, look about you."