Aching muscles and joints

The virus will directly attack muscle tissue after being bitten by an African fly. When entering the body, the virus attaches to the cell as a parasite, causing the cell to die in large numbers. The dead cells will release damage-associated molecules (DAMP) that stimulate the body's innate immune system at a moderate level to help the body recover quickly. Sometimes this situation is exaggerated leading to the formation of Cytokine storms that cause persistent muscle and joint pain.

Next, through an inflammatory response that leads to increased blood lactate levels, decreased intracellular pH, and low oxygen levels, causing muscle fatigue similar to muscle fatigue after strenuous exercise. Hypercoagulability and inflammation of blood vessels in and around nerves and muscles aggravate the lack of blood supply to the muscle. Patients often experience muscle aches, and pain in the limbs and joints. If the African Trypanosomiasis condition persists for a long time, it can lead to paralysis, so you need to see a doctor as soon as the initial symptoms appear.