Combination Therapy

Amlodipine can be administered in conjunction with a number of drugs, including:

• Amlodipine/atorvastatin, where atorvastatin reduces cardiovascular events or if the patient also has excessive cholesterol and amlodipine is taken for hypertension or CAD.
• If Amlodipine alone is unable to lower blood pressure, amlodipine/aliskiren or amlodipine/aliskiren/hydrochlorothiazide. A renin inhibitor, such as aliskiren, prevents renin from starting the renin-angiotensin system (RAAS) pathway that raises blood pressure, hence lowering primary hypertension (hypertension with no known cause). Diuretic hydrochlorothiazide reduces total blood volume.
• If either medication has been ineffective on its own or if amlodipine alone produced edema, try amlodipine/benazepril. An ACE inhibitor, benazepril prevents the RAAS pathway from converting angiotensin I to angiotensin II.
• Amlodipine/celecoxib
• Amlodipine/lisinopril
• If amlodipine is ineffective at lowering blood pressure, other options include amlodipine/olmesartan and hydrochlorothiazide. Olmesartan blocks a portion of the RAAS pathway and is an angiotensin II receptor antagonist...