Drawbacks

You are more likely to have the following side effects if you are between the ages of 18 and 60, do not take any other medications, or have any other medical conditions:

• A backache, joint discomfort, nausea, dyspepsia, headache, nasal and sinus congestion, or rash.
• In bone-forming tissue, tetracyclines—including doxycycline—form a persistent calcium complex. This may have an impact on a fetus's skeletal development as well as young children's fibula growth rates.
• Can result in enamel hypoplasia (underdeveloped tooth enamel) or permanent tooth discoloration (usually yellow-gray-brown staining) if used during crucial stages of tooth development, including the second half of pregnancy or in young children under the age of eight. Short-term use has been noticed, however long-term use carries a higher risk.
• Most medications, including doxycycline, have been linked to the severe, chronic diarrhea caused by Clostridium difficile. If chronic diarrhea develops within two months of taking doxycycline, seek medical attention.
• An increased incidence of vaginal candidiasis has also been linked to using antibiotics like doxycycline (thrush).
• Cross-resistance occurs frequently. This suggests that bacteria are likely to be resistant to doxycycline if they are resistant to other tetracyclines.
• Some people, such as those who are pregnant, nursing, or have young children under the age of eight, may not be able to use it.
• Some medications, such as anticoagulants, penicillins, antacids or iron-containing preparations, antiepileptics, and oral contraceptives, may interact with one another.
• Your risk of sunburn may increase if you use doxycycline since it may make your skin more sun-sensitive.
• Using doxycycline has been linked to a higher risk of developing inflammatory bowel disease. Patients who had doxycycline for their acne had a 2.25-fold higher risk of getting Crohn's disease, according to a significant retrospective study.