Drug interactions
When using any form of clindamycin, drug interactions may occur. Anesthesiologists have previously expressed concern that clindamycin could delay the effectiveness of neuromuscular blocking agents during surgery.
However, researchers have recently discovered that the drug may enhance the effect of a blocking agent.
Clindamycin is broken down in the body by the liver enzyme CYP3A4 when it is taken orally. Clindamycin levels can be reduced by stimulating the function of this enzyme. Clindamycin levels in the blood may rise if something inhibits CYP3A4.
Certain drugs can impair CYP3A4 function. Doctors must monitor patients who are taking CYP3A4 stimulants in conjunction with clindamycin to ensure that the antibiotic is effective.
If a person takes clindamycin with a CYP3A4 inhibitor, the increased levels of the antibiotic may cause side effects. Doctors should keep an eye out for any increase in adverse effects.
