Florence

This little city, tucked amid the Tuscan hills, casts a long shadow through history. The wellspring of the Renaissance, Firenze (or Florence) sheltered the powerful Medici family and inspired artists like Michelangelo (David) and Brunelleschi (the Duomo). If it weren't for the fashionable Italians and chic shops lining Via Tornabuoni, you might think you had traveled back in time to the 14th century.

But Renaissance art is not the only reason to come. You also visit Florence for its gorgeous sunsets, Italian cooking, and its romantic charm. Make the most of your time in the city by letting a local show you around on one of Florence's best tours. Florence is known not only for its famous art but also for its simple yet delicious cuisine, as well as its wine from neighboring towns in Tuscany. While restaurants tend to be overpriced, you can do as the Italians do and head to Mercato Centrale Firenze for fresh produce, bread, cheese, and meat and create your own meal.

• Country: Italy
• Best Hotels: St. Regis Florence, Four Seasons Hotel Firenze, Portrait Firenze
• Best Things to Do: Piazza della Signoria, Duomo (Cathedral of Santa Maria del Fiore), Piazzale Michelangelo
• Best Months to Visit: Between May and September