Harrison's Principles of Internal Medicine

Hersey Professor of the Theory and Practice of Medicine at Harvard Medical School, Chairman of the Department of Medicine, and Physician-in-Chief of Brigham and Women's Hospital, Joseph Loscalzo, MD, PhD


Anthony S. Fauci, MD, is the Director of the National Institutes of Allergy and Infectious Diseases and the Chief of the Laboratory of Immunoregulation at the National Institutes of Health.


At Harvard Medical School, Dennis L. Kasper, MD, is the William Emery Channing Professor of Medicine and Professor of Microbiology and Molecular Genetics.


Stephen L. Hauser, MD, is the Robert A. Fishman Distinguished Professor of Neurology and the Director of the University of California, San Francisco's Weill Institute for Neurosciences.


Dan L. Longo, MD, is a Harvard University School of Medicine Professor of Medicine and the New England Journal of Medicine's Deputy Editor of Oncology.


J. Larry Jameson, MD, PhD, is the Robert G. Dunlop Professor of Medicine, Dean of the Raymond and Ruth Perelman School of Medicine, and Executive Vice President for the Health System at the University of Pennsylvania.


Harrison's Principles of Internal Medicine is the most trusted clinical medicine text in the world, and it is an excellent resource for understanding the art and science of clinical reasoning. Harrison's Principles of Internal Medicine, recognized by healthcare professionals worldwide as the premier authority on applied pathophysiology and clinical medicine, provides the informational foundation you need to give the finest patient care possible. This new edition has been completely updated, with new chapters and important revisions covering the entire range of internal medicine.


This landmark handbook, written and edited by the world's leading specialists in their respective professions, provides comprehensive, accurate, and vital coverage of illness causation, diagnosis, and therapy.


Harrison's is well-known around the world as the most authoritative source for:

  • Clear, succinct schemas that aid in the production of differential diagnoses so that complex real-world clinical cases can be reasoned through rapidly.
  • The physiologic and etiologic foundation of signs and symptoms, which are explored in depth by an abundance of unrivaled expert advice and related to the disease-specific chapters that follow.
  • Clinical trial results and recommendations have been updated.
  • Extensive visual assistance, including radiographs, clinical photographs, schematics, and high-quality drawings
  • Coverage of both therapeutic approaches and specific treatment regimens
  • Clinical decision trees and algorithms in practice
  • Organ/system-specific sections with clinically relevant pathophysiology and practical clinical advice on patient management, strategies for developing a differential diagnosis, outstanding clinical algorithms and diagnostic schema, a wealth of clinical images and diagrams, current clinical guidelines, and general and specific approaches to therapy


In a world affected by an infinite number of medical knowledge sources, Harrison's remains the most trusted resource. The 21st edition includes the most recent and thorough updates from the world's best experts:

  • Current coverage of disease diagnosis and treatment, including COVID, dementia, sepsis, multiple sclerosis, and lung cancer.
  • Content has been updated to reflect new authorized treatments as well as new practice-changing guidelines and evidence summaries.
  • Over 1000 clinical, pathological, and radiographic pictures, as well as diagnostic and therapeutic decision trees and comprehensive schematics and diagrams detailing pathophysiologic processes
  • Several atlases provide curated collections of significant visual components of diagnosis and management
  • Clinically relevant coverage of disease mechanics and pathophysiology, as well as related treatment mechanisms
  • Updated and time-saving curation and synthesis of old and novel medical literature and studies


Author: Stephen L. Hauser, Dan L. Longo, J. Larry Jameson, Anthony S. Fauci, Dennis L. Kasper and Joseph Loscalzo

Link to buy: https://www.amazon.com/Harrisons-Principles-Internal-Medicine-Twenty-First/dp/1264268505/

Ratings: 4.6 out of 5 stars (from 76 reviews)

Best Sellers Rank: #16,066 in Books

#1 in Diseases

#9 in Internal Medicine (Books)

#108 in Medical Diseases (Books)

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