How does fentanyl affect the brain?

Fentanyl binds to the same brain receptors that control pain and emotion as do other opioid drugs. This results in feelings of happiness (euphoria), relaxation, and pain relief.

Everyone is affected by fentanyl differently. The following factors determine an individual's effects:

• size
• weight
• overall state of health

The effects are also dependent on:

• the amount a person takes
• whether they take it in combination with other drugs
• whether the person is used to taking opioids

However, over time, fentanyl causes the brain to adapt, making it challenging for an individual to feel happy or content for reasons other than taking the drug. Addiction may result from this.