Interactions
When combined with Brilinta, medications that interact with it may either lessen its effect, shorten its duration of action, exacerbate side effects, or have no effect at all. Even though it is not always necessary to stop taking one of the drugs, sometimes there is an interaction between two drugs. Consult your doctor to learn how to handle drug interactions.
Over 400 drugs can interact negatively with Brilinta. Typical drugs with which Brilinta may interact are:
- aspirin (dosages greater than 100mg)
- amiodarone
- apalutamide
- apixaban
- aprepitant
- bismuth subsalicylate
- calcium channel blockers such as diltiazem or verapamil
- cholesterol-lowering agents, such as simvastatin or lovastatin
- cobicistat
- dabigatran
- dalteparin
- digoxin
- erythromycin
- fluconazole, ketoconazole, or voriconazole
- grapefruit juice
- herbals, such as Dong Quai or echinacea
- mifepristone
- NSAIDs, such as celecoxib, ibuprofen, diclofenac, etodolac, and naproxen
- opioids, such as methadone, morphine, or oxycodone (can delay and reduce the absorption of Brilinta and its active metabolite possibly due to slowed gastric emptying)
- repaglinide
- steroids such as dexamethasone
- strong CYP3A inducers such as rifampin, phenytoin, carbamazepine, and phenobarbital (substantially reduce the efficacy of Brilinta).
- strong CYP3A inhibitors such as itraconazole, ketoconazole, voriconazole, clarithromycin, nefazodone, atazanavir, indinavir, nelfinavir, ritonavir, saquinavir, and telithromycin (substantially increase the risk of side effects such as dyspnea or bleeding).
- ticlopidine
- tinzaparin
- tramadol
- warfarin and other anticoagulants.
In general, Brilinta may interact with any medication that raises the risk of bleeding, including aspirin, corticosteroids, SSRI antidepressants (citalopram, duloxetine, fluoxetine, venlafaxine), enoxaparin, and fish oils.
Note that only common medications that may interact with Brilinta are included in this list, which is not exhaustive. For a comprehensive list of interactions, consult the Brilinta prescribing information.
