Interactions

Medicines that interact with Dupixent may reduce its effect, shorten its duration of action, increase side effects, or have no effect when combined. An interaction between two medications does not always necessitate the discontinuation of one of them; however, it can. Consult your doctor about how to handle drug interactions.

Among the medications that may interact with Dupixent are:

• etanercept
• herbals, such as brewers yeast
• immunosuppressants (such as azathioprine, cyclosporine, or tacrolimus)
• live vaccines and some other vaccines, such as BCG, cholera, measles, or hepatitis b vaccines
• medications used to treat multiple sclerosis, such as fingolimod
• other biologics, such as adalimumab, golimumab, or infliximab
• probiotics, such as bifidobacterium lactobacillus
• warfarin
• zinc.

Any drug that is metabolized by CYP450 enzymes, especially those with a restricted therapeutic index (such cyclosporine or warfarin), carries the risk of interfering with Dupixent. This is due to the possibility that elevated amounts of specific cytokines (like IL-13) during chronic inflammation may affect how CYP450 enzymes are formed. Dupixent prevents IL-4 and IL-13 from interacting with their receptors, which may restore normal CYP450 enzyme synthesis. Keep an eye out for any change in the effect and think about changing the dosage.

Note that only commonly used drugs that may interact with Dupixent are included in this list, which is not exhaustive. For a comprehensive list of interactions, consult the Dupixent prescription instructions.