Interactions

Medicines that interact with Prozac may reduce its effect, shorten its duration of action, increase side effects, or have no effect when combined. An interaction between two medications does not always necessitate the discontinuation of one of them; however, it can. Consult your doctor about how to handle drug interactions.

Prozac may interact with the following medications:

• anticoagulants (blood thinners), such as warfarin, or other drugs that have blood-thinning effects such as aspirin or NSAIDs
• anticonvulsants, such as phenytoin, phenobarbital, or primidone
• antipsychotics (such as butyrophenones, phenothiazines, or thioxanthenes) and atypical antipsychotics (eg, olanzapine, quetiapine, ziprasidone)
• any medication that may cause drowsiness, such as benzodiazepines (eg, diazepam, lorazepam), first-generation antihistamines (such as doxylamine or promethazine), metoclopramide, or opioids (such as codeine, morphine)
• diuretics, such as furosemide
• lithium
• medications that may affect the heartbeat by prolonging the QT interval, such as amiodarone, encainide, or flecainide
  pimozide
• other antidepressants, such as tricyclic antidepressants (eg, amitriptyline), monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine), and SSRIs (eg, paroxetine, sertraline)
• other medications that affect serotonin, such as amphetamines, fentanyl, lithium, tramadol, triptans (eg, almotriptan, eletriptan, or sumatriptan), or St. John's Wort
• other medications that are metabolized by the same enzymes (CYP2D6) such as tricyclic antidepressants, most antipsychotics, flecainide, propafenone, or vinblastine
• thioridazine (do not administer at the same time as Prozac or for 5 weeks after Prozac has been discontinued)
  others, such as HIV medications (fosamprenavir, ritonavir), procyclidine, or theophylline.

While taking Prozac, avoid drinking alcohol or using illegal or recreational drugs.

It should be noted that this list is not exhaustive and only includes common medications that may interact with Prozac. For a complete list of Prozac interactions, consult the prescribing information.