Letoon of Xanthos was the famous sanctuary of Leto

Many temples in Ancient Greece were devoted to Leto, and she was greatly venerated there. She was loved and respected for her kindness. They revered Leto as a protector of mothers, children, and families as well.

Although her worship was particularly strong in Lycia, the Goddess's homeland, her religion was primarily concentrated on Anatolia's southern coast. South of Letoon, Xanthos, Lycia, a few kilometers lay the sanctuary of Leto. There, she and her twins were revered as domestic goddesses, national goddesses, and tomb guardians.

She purportedly had a temple in Egypt that was joined to a floating island in Buto named "Khemmis," which also housed a temple dedicated to an Apollo like Egyptian deity that Greek interpreters identified as such. There, the cobra-headed deity of Lower Egypt known to the Greeks as Leto was revered.