The virus mutates so fast that a vaccine will never work.

While all viruses continually mutate, the World Health Organization stated in December 2020 that "SARS-CoV-2, the virus that causes COVID-19, tends to change more slowly than others like HIV or influenza viruses". The flu vaccination is updated annually due to the faster mutations in influenza viruses.

Preliminary laboratory investigations on the first two COVID-19 vaccines approved for use in the United States — one developed by Pfizer/BioNTech and the other by Moderna — indicated that their vaccinations are still effective against the B.1.1.7 strain, which was initially detected in the United Kingdom. Although the research indicated that immunizations were less effective against the B.1.351 mutation seen in South Africa, there was no indication that the mutations would completely invalidate the advantages of the vaccines.

"You might reduce the vaccine-induced antibody effectiveness by a few folds and still be well within the vaccine's protective range", Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases in the United States, said in a White House briefing on Jan. 27, 2021.