Upsides

Clonidine may be used to treat high blood pressure when all other treatments have failed. It is usually used in conjunction with other medications to treat high blood pressure.

Slow-release formulations (Kapvay brand) may be used to treat ADHD (Attention Deficit Hyperactivity Disorder) in children over the age of six.

Off-label use for other conditions such as Tourette's syndrome is also possible (off-label means not an FDA-approved use but experts consider it still has a place in therapy).

There are three formulations available: an oral tablet, a transdermal patch, and an oral extended-release tablet. The transdermal patch may have fewer side effects than the oral form of the drug, but people who use it should be monitored for the appearance of a rash.

Clonidine is available in generic form.