Water
Given that it covers nearly two-thirds of the planet's surface and is stored in smaller streams, rivers, lakes, and glaciers, water is by far the most plentiful natural substance on Earth. But despite this, there is a severe water shortage in many regions of the world right now, a problem that has only gotten worse as a result of all the recent high heat-related weather events.
Although there isn't a serious water shortage on Earth, the most of it is in the oceans, and desalination on a wide scale is still not a practical solution. The majority of the freshwater we have is either scarce and trapped in geological formations like glaciers, or it is dispersed unevenly and is expensive to transfer.
There are currently 844 million people without access to clean water in the world, and this number is expected to rise over the next several years. We're looking at a future where water would be a much scarcer and valuable resource than it is now. Add all of that together with climate change and its anticipated implications in the coming years.