Downsides

You are more likely to experience the following side effects if you are between the ages of 18 and 60, do not take any other medications, or have any other medical conditions:

• The most frequent side effects include low blood pressure, elevated potassium levels in the blood, a cough, lightheadedness, and kidney dysfunction. People who have previously taken other medications that have caused coughs, such as ACE inhibitors, are at a higher risk of developing one. Those who are receiving diuretic therapy, have sodium deficiency, or are dehydrated have a higher risk of developing low blood pressure.
• Angioedema is a rapid swelling beneath the skin and mucus membranes that is usually associated with an allergy to a specific substance, in this case, Entresto. Discontinue Entresto immediately, and if necessary, provide airway support and other appropriate therapy. Do not reintroduce Entresto.
• Gastrointestinal disturbances, sinusitis, stuffy nose, low sodium levels, joint pain, back pain, and muscle cramps may also occur.
• Entresto may not be appropriate for some people who have pre-existing kidney disease, liver disease, severe heart failure, or dehydration; or additional monitoring may be required.
• Lithium, aliskiren, NSAIDs, and potassium supplements may interact with this medication.
• If used during pregnancy, it can result in severe birth defects and fetal death. Entresto should not be given to pregnant women and should be stopped immediately if pregnancy is detected unless no other treatment is available and the benefits outweigh the risks.
• Entresto should be gradually increased over two to four weeks. Adults should begin with Entresto 49/51mg twice daily, which should be increased to Entresto 97/103mg twice daily after two to four weeks. Children can be given an oral suspension made from crushed Entresto 49/51mg tablets mixed with Ora-Plus and Ora-Sweet. Children's dosages are determined by their weight.
• In patients with liver disease, the dosage must be adjusted.
• Potassium levels and kidney function should be checked on a regular basis.
• Patients should be monitored for signs and symptoms of heart failure once Entresto is started. BNP levels should not be used as an indicator of heart failure because Entresto inhibits BNP breakdown and thus raises them.
• There is no generic version available.

In general, people who are older or younger, have certain medical conditions (like liver or kidney issues, heart disease, diabetes, or seizure disorders), take other medications, or are seniors or young children are more likely to experience a wider range of side effects.