Interactions

Medicines that interact with Entresto may reduce its effect, shorten its duration of action, increase side effects, or have no effect when combined. An interaction between two medications does not always necessitate the discontinuation of one of them; however, it can. Consult your doctor about how to handle drug interactions.

Entresto may interact with the following medications:

• antipsychotics, such as aripiprazole, clozapine, or haloperidol
• aspirin
• bupropion
• buprenorphine
• corticosteroids, such as budesonide, betamethasone, or prednisone
• cyclosporine
• heart medications, including all ACE inhibitors or ARBs, such as benazepril, captopril, fosinopril, or lisinopril
• insulin
• NSAIDs, such as diclofenac, ibuprofen, or indomethacin
• other heart medications, such as amiodarone, clonidine, digoxin, diltiazem, propafenone, quinidine, and verapamil
• other medications including celecoxib, clonidine, hydralazine, and rifampicin
• potassium salts
• potassium-sparing diuretics such as spironolactone, triamterene, or amiloride
• sildenafil
• trimethoprim
• zolpidem.

People taking oral diabetes medications may need to consult their doctor about adjusting the dose of their medication.

Please keep in mind that this list is not exhaustive and only includes common medications that may interact with Entresto. For a complete list of interactions, consult the Entresto prescribing information.