Drawbacks

The most typical adverse effects include dry mouth, sleepiness, dizziness, constipation, and weight gain, which affect 20% or more of users (on average 1.8 kg). Vision issues (amblyopia, blurred vision), tachycardia, increased hunger, tremor, fatigue/asthenia/feeling slowed down, and dyspepsia are other frequent side effects (in 10% or more). This is also the next thing to know about Amitriptyline.

• Young adults may be more likely to have suicide thoughts or act out in this situation (similar to other antidepressants).
• May make a person drowsy and impair their ability to drive or operate machinery; some individuals may get tolerant to this effect.
• Risk of edema, weight gain or loss, hair loss, skin rash, seizures, muscle rigidity, tremor, and heart-related side effects.
• Serotonin syndrome may result from an interaction or an overdose (symptoms include agitation, hallucinations, fast heart rate, dizziness, muscle tremor, nausea, vomiting, diarrhea). After starting or increasing the dose of amitriptyline, reports of the rare neuroleptic malignant syndrome (NMS) have been made. Muscle rigidity, fever, altered mental status, a rapid heartbeat, and tremors are some symptoms.
• With sudden discontinuance, withdrawal symptoms could develop (symptoms include nausea, headache, sleep disturbance, and generalized tiredness). These don't point to addiction. Under medical guidance, gradually reduce the dosage. Rare cases of mania have been documented within 2 to 7 days after tricyclic antidepressants, such amitriptyline, were stopped as a chronic treatment for depression.
• Some persons, such as those with undiagnosed bipolar disorder, a history of seizures, urinary retention, or angle-closure glaucoma, may not be a good candidate for this medication. Amitriptyline should not be used in high doses to patients with cardiovascular problems. It is advised to give under supervision to those with thyroid disorders.
• May result in a modest increase in pupil size, which could lead to an attack of angle-closure glaucoma.
• May interact with a number of different medications, such as those metabolized by the hepatic enzyme CYP2D6 or those that have sedative effects or anticholinergic adverse effects (such as dry mouth, urinary retention, blurred vision, constipation). Amitriptyline has been known to cause extremely high fevers (hyperpyrexia) when combined with antipsychotics or anticholinergic medications.
• If the dangers are not outweighed by the benefits, avoid using during pregnancy. Although a causative connection has not been shown, amitriptyline has been demonstrated to pass the placenta and there have been a few instances of unfavorable consequences.