How It Works

How Amitriptyline works is the first thing to know about Amitriptyline.

• Amitriptyline may be utilized off-label to treat insomnia, fibromyalgia, and chronic pain in addition to treating depression.
• Although it was once thought that amitriptyline's effects on depression were caused by its capacity to rebalance neurotransmitters in the brain like serotonin and/or norepinephrine, experts are unsure exactly how amitriptyline functions. Despite the fact that its exact mechanism of action is uncertain, studies show that amitriptyline is still useful in treating mood disorders including depression. Amitriptyline's mechanism of action in treating chronic pain, fibromyalgia, or sleeplessness is unknown.
• Amitriptyline is a member of the tricyclic antidepressant class of drugs.