Interactions

Medicines that interact with Cosentyx may reduce its effect, shorten its duration of action, increase side effects, or have no effect when combined. An interaction between two medications does not always necessitate the discontinuation of one of them; however, it can. Consult your doctor about how to handle drug interactions.

Cosentyx may interact with the following medications:

• aminophylline
• anticonvulsants, such as phenobarbital,
• benzodiazepines, such as alprazolam or clonazepam
• chemotherapy agents, such as cyclophosphamide, methotrexate, or bleomycin
• corticosteroids (such as prednisone or dexamethasone)
• cyclosporine
• heart medications such as amiodarone or flecainide
• herbals, such as echinacea
• hormones such as levonorgestrel or norgestrel
• immunosuppressants (such as azathioprine, cyclosporine, or tacrolimus)
• live vaccines and some other non-live vaccines, such as BCG, cholera, measles, or hepatitis b vaccines
• opioids, such as fentanyl or oxycodone
• other biologics, such as adalimumab, golimumab, or infliximab
• probiotics, such as lactobacillus
• statins, such as atorvastatin or simvastatin
• theophylline
• warfarin
• zinc.

Any medication that is metabolized by CYP450 enzymes, particularly those with a narrow therapeutic index (such as cyclosporine or warfarin), has the potential to interact with Cosentyx. This is because increased levels of certain cytokines (such as IL-1, IL-6, IL-10, and IL-17) during chronic inflammation can alter the formation of CYP450 enzymes. Because Cosentyx prevents IL-17A from interacting with the IL-17 receptor, it may restore CYP450 enzyme formation. Keep an eye out for any changes and consider changing the dosage if necessary.

It should be noted that this list is not exhaustive and only includes common medications that may interact with Cosentyx. For a complete list of interactions, consult the Cosentyx prescribing information.