Interactions
Medicines that interact with Enbrel may reduce its effect, shorten its duration of action, increase side effects, or have no effect when combined. An interaction between two medications does not always necessitate the discontinuation of one of them; however, it can. Consult your doctor about how to handle drug interactions.
Enbrel interacts with over 387 medications, with the majority of these interactions being classified as major or moderate. Enbrel may interact with the following medications:
- benzodiazepines such as clonazepam or diazepam
- bleomycin
- capecitabine, carboplatin, cyclophosphamide
- cholesterol-lowering agents such as atorvastatin or fluvastatin
- cladribine
- heart medications such as amiodarone or nifedipine
- hormones such as ethinylestradiol or levonorgestrel
- hydroxyurea
- immunosuppressants such as azathioprine or cyclosporine
- interferon or peginterferon
- live vaccines such as measles, mumps, rubella, yellow fever, varicella, or zoster vaccines
- methotrexate
- opioids such as methadone
- other biologics, such as adalimumab, anakinra, abatacept, golimumab, or infliximab
- sulfasalazine
- steroids such as betamethasone and dexamethasone
- thalidomide
- theophylline
- warfarin.
People who have had significant varicella virus exposure should temporarily stop taking Enbrel and be considered for prophylactic treatment with varicella zoster immune globulin.
If a doctor has recommended antibiotics for a patient with a current bacterial illness, they may be used with this medication. While the patient is undergoing therapy for the illness, a doctor may decide to cease Enbrel, either temporarily or permanently, if the patient gets a major infection or sepsis.
Note that only commonly used drugs that may interact with Enbrel are included in this list, which is not exhaustive. For a comprehensive list of interactions, consult the Enbrel prescribing instructions.
