Response and effectiveness

It begins to have an effect within one to two weeks, but the full effects may take 3 to 6 months to develop.

The American College of Rheumatology (ACR) response is a measurement used in trials looking at Enbrel's effectiveness. Here is how this is explained: ACR 50: A 50% reduction in the number of painful and swollen joints, as well as a 50% reduction in three of the five criteria listed below: erythrocyte sedimentation rate or C-reactive protein (CRP), patient global assessment, physician global assessment, functional ability measure (most commonly the Health Assessment Questionnaire (HAQ)), visual analog pain scale, and functional ability measure (functional ability measure). In other studies, by the third month, over 42% of participants had a confirmed clinical response (ACR 50) and 15% had a strong clinical response (ACR 70).

Additionally, studies have demonstrated that taking Enbrel along with methotrexate improves responsiveness.