Interactions
When combined with hydrocodone, certain medications may lessen its effects, shorten their duration, cause more side effects, or have no effect at all. Even though it is not always necessary to stop taking one of the drugs, sometimes there is an interaction between two drugs. Consult your doctor to learn how to handle drug interactions.
Typical drugs with which hydrocodone may interact are:
- antibiotics, such as erythromycin
- anticholinergics, such as benztropine (may increase the risk of urinary retention or severe constipation)
- antidepressants, such as tricyclic antidepressants (eg, amitriptyline), monoamine oxidase inhibitors (eg, isocarboxazid, phenelzine, and tranylcypromine), or SSRIs (eg, fluoxetine, sertraline). May increase the risk of serotonin syndrome
- antiemetics, such as dolasetron, granisetron, or ondansetron
- antifungal agents, such as itraconazole and ketoconazole
- anticonvulsants, such as carbamazepine, lamotrigine, phenytoin, phenobarbital, or primidone
- antimigraine agents such as sumatriptan
- antipsychotics (such as butyrophenones, phenothiazines, or thioxanthenes) and atypical antipsychotics (eg, olanzapine, quetiapine, ziprasidone)
- aprepitant
- azelastine
- any medication that may cause drowsiness, such as amphetamines, benzodiazepines (eg, diazepam, lorazepam), first-generation antihistamines (such as doxylamine or promethazine), metoclopramide, or opioids (such as codeine, morphine)
- buprenorphine
- buspirone
- cannabidiol
- cannabis
- desmopressin
- dextromethorphan
- diuretics, such as furosemide
- fusidic acid
- gastrointestinal agents, such as metoclopramide
- HIV medications such as ritonavir
- kava kava
- ketoconazole
- magnesium sulfate
- mifepristone
- muscle relaxants, such as cyclobenzaprine
- naltrexone
- other medications that are CYP3A4 or CYP2D6 inhibitors or inducers
- pentazocine
- rifampin
- sedative-hypnotic agents such as zolpidem or eszopiclone.
While taking hydrocodone, avoid drinking alcohol or using illegal or recreational drugs.
It should be noted that this list is not exhaustive and only includes common medications that may interact with hydrocodone. For a complete list of interactions, consult the hydrocodone prescribing information.
