Response and effectiveness

Hysingla ER takes 6 to 30 hours to peak after oral administration, Vantrela ER takes 8 hours, and Zohydro R takes 5 hours.

Hydrocodone is metabolized by hepatic enzymes CYP2D6 to hydromorphone, which is the main metabolite of hydrocodone and has a 10 to 33-fold higher binding affinity (in some cases up to a 100-fold higher binding affinity) for the mu receptor than hydrocodone. Other hepatic enzymes are involved in the elimination of hydrocodone that has been metabolized.

Because CYP2D6 is genetically polymorphic, there may be a wide interindividual variation in how people respond to hydrocodone.

One dose of Hysingla ER is effective for 24 hours, whereas one dose of Vantrela ER or Zohydro ER is effective for 12 hours.