Response and effectiveness

Improvements in sleep, energy, or appetite may be noticeable within the first 1-2 weeks of taking bupropion for depression. It may take up to 6-8 weeks to fully recover from a depressed mood or motivation.


Bupropion reduces nicotine cravings and withdrawal symptoms, but the effects take one to two weeks to manifest.


Once in the body, bupropion is metabolized into three active metabolites, each with a different duration of action.

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UChicago Medicine
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Top 7 Things to Know About Bupropion

  1. top 1 How it works
  2. top 2 Upsides
  3. top 3 Downsides
  4. top 4 Bottom Line
  5. top 5 Tips
  6. top 6 Response and effectiveness
  7. top 7 Interactions

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