Upsides

Bupropion may be used to treat depression symptoms in Major Depressive Disorder (MDD) and Seasonal Affective Disorder (SAD).

When first-line agents are ineffective or not tolerated, this medication may be considered second-line for the treatment of bipolar depression.

Bupropion (Zyban brand, generic bupropion) may be used to relieve nicotine withdrawal cravings during smoking cessation. According to research, Zyban treatment is far more effective than no treatment in helping people quit smoking. Although blood pressure should be monitored, Zyban can be combined with a Nicotine Transdermal System (nicotine patches).

Can be used off-label for attention deficit hyperactivity disorder (ADHD); this is not an FDA-approved use, but some professional organizations consider it a possibility if standard treatments are ineffective or poorly tolerated.

Bupropion is available in generic form, and it is also marketed under the brand names Aplenzin (for depression) and Zyban (for smoking cessation).