Upsides

Ezetimibe can be taken with or without other cholesterol-lowering medications such as statins, fenofibrate, or bile-acid sequestrants. These medications work in a different manner and complement ezetimibe.

In the United States, ezetimibe is available as a generic product in a 10 mg tablet and is very affordable. It is also available under the brand name Zetia, which is manufactured by Organon.

Ezetimibe is taken once a day as an oral tablet that is swallowed with or without food. The typical daily dose is 10 mg.
There are no recommended dosage adjustments for people with kidney disease, mild liver disease, or advanced age; however, ezetimibe is not recommended for people with moderate to severe liver disease.

When ezetimibe is used alone (without a statin), no increase in liver enzymes has been observed in studies. Some older people may be more sensitive than others. Ezetimibe has not been shown to cause changes in blood pressure.

Ezetimibe is also available in combination products, which may be more convenient. Brand-name products that contain both ezetimibe and a statin include Vytorin (ezetimibe and simvastatin) and Roszet (ezetimibe and rosuvastatin). These brands are also available as generics at a lower cost.

Ezetimibe can also be taken in combination with bempedoic acid (brand name: Nexlizet), a non-statin cholesterol-lowering medication. Bempedoic acid reduces the amount of cholesterol produced in the liver.