Warnings and Interactions
Top 5 in Top 6 Things to Know About Imbruvica
Imbruvica can generally coexist with other drugs and substances. However, when used in conjunction with a class of drugs known as CYP3A inhibitors, dosages may need to be reduced. This includes a variety of prescribed medications, including:
- Clarithromycin (e.g., Biaxin)
- Diltiazem (e.g., Cardizem, Tiazac)
- Erythromycin (e.g., Erythrocin)
- Ritonavir (e.g., Norvir)
- Itraconazole (e.g., Sporanox, Tolsura)
- Verapamil (e.g., Verelan, Calan SR)
- Ketoconazole (e.g., Xolegel, Extina)
- Voriconazole (e.g., Vfend)
- Posaconazole (e.g., Noxafil)
Furthermore, some other medications, foods, herbs, and supplements have been found to influence CYP3A inhibition, which may affect Imbruvica function. These are some examples:
- Goldenseal
- Phenobarbital
- Phenytoin (e.g., Phenytek, Dilantin)
- Rifampin (e.g., Rifadin)
- St. John’s wort
