Downsides

If you are between the ages of 18 and 60, do not take any other medications, and have no other medical issues, you are more likely to have the following negative effects:

• The most common adverse effects recorded include headaches, gastrointestinal difficulties (e.g., constipation, nausea, or vomiting), pain, withdrawal syndrome, infection, sleeplessness, perspiration, and rhinitis. Elevations in liver enzymes (for example, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase) and blood creatine phosphokinase have also been documented.
• Has the potential to cause significant, maybe fatal respiratory issues. This is especially common in those who abuse Zubsolv or when it is used with other drugs that impair respiration, such as benzodiazepines. Children, the elderly or disabled, and individuals with pre-existing respiratory difficulties are also more vulnerable.
• Even at the recommended dosage, it may become habit-forming. Zubsolv is a category III prohibited drug that must be prescribed and distributed with prudence to reduce the risk of overuse, abuse, or diversion.
• There have been reports of allergic responses (including breathing difficulty, rash, and anaphylactic shock) and liver damage (hepatitis). Zubsolv should not be used in individuals who have a history of buprenorphine hypersensitivity.
  It can make you sleepy or dizzy, and it can impair your ability to drive or operate machines. It is best to avoid alcohol.
  May result in a dramatic drop in blood pressure or a quick reduction in blood pressure upon rising from a seated position.
• At larger doses, there is a risk of cardiac rhythm abnormalities (such as QT prolongation).